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kanadaptin (kidney anion exchanger adapter protein, solute carrier family 4 member 1 adapter protein, lung cancer oncogene 3 protein, SLC4A1AP, HLC3)
Function:
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure: contains 1 FHA domain
Compartment:
- nucleus, cytoplasm
- mainly nuclear
- small amounts are found in the cytoplasm
Expression: ubiquitously expressed
Note: initially suggested a role in targeting SLC4A1 to the plasma membrane, but does not interact with SLC4A1 & has no effect on SLC4A1 trafficking
General
nuclear protein
phosphoprotein
solute carrier family 4 (SLC4, SLC4A)
Properties
SIZE: MW = 89 kD
entity length = 796 aa
COMPARTMENT: cell nucleus
MOTIF: forkhead-associated (FHA) domain {189-249}
Ser phosphorylation site {S312}
Ser phosphorylation site {S466}
coiled coil {497-530}
MOTIF: Ser phosphorylation site {S524}
Ser phosphorylation site {S530}
Ser phosphorylation site {S532}
glutamate-rich region {644-715}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S709}
Ser phosphorylation site {S712}
Database Correlations
OMIM 602655
UniProt Q9BWU0
PFAM correlations
Kegg hsa:2295
References
- UniProt :accession Q9BWU0
- Wikipedia; Band 3 entry
http://en.wikipedia.org/wiki/Band_3