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Anosmin-1; kallmann syndrome protein; Adhesion molecule-like X-linked (KAL1, ADMLX, KAL, KALIG1)
Function:
- adhesion-like molecule with anti-protease activity
Structure:
1) N-glycosylated
2) contains 4 fibronectin F3 modules
- contains 1 WAP domain
Compartment: cell surface
Pathology:
- defects in KAL1 are the cause of Kallmann syndrome 1
Related
Kallmann syndrome; hypogonadotropic hypogonadism & anosmia
General
adhesion receptor
glycoprotein
serine protease inhibitor; serpin
Properties
SIZE: entity length = 680 aa
MW = 76 kD
COMPARTMENT: plasma membrane
MOTIF: signal sequence {1-24}
N-glycosylation site {N71}
WAP {127-176}
fibronectin type III domain or F3 module {183-284}
MOTIF: N-glycosylation site {N209}
fibronectin type III domain or F3 module {290-394}
MOTIF: N-glycosylation site {N300}
fibronectin type III domain or F3 module {425-520}
MOTIF: N-glycosylation site {N470}
fibronectin type III domain or F3 module {547-652}
MOTIF: N-glycosylation site {N553}
N-glycosylation site {N564}
INHIBITS: serine protease
Database Correlations
OMIM correlations
UniProt P23352
PFAM correlations
Kegg hsa:3730
References
- UniProt :accession P23352
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=KAL1