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kallikrein-5 (stratum corneum tryptic enzyme, SCTE, kallikrein-like protein 2, KLK-L2)
Function:
- role in desquamation
Structure:
- belongs to the peptidase S1 family, kallikrein subfamily
- contains 1 peptidase S1 domain
Compartment: secreted
Expression:
- expressed in skin, breast, brain, testis
Pathology:
- overexpression of kallikrein-5 cleaves cathelicidin thus producing clinical manifestations of rosacea [3]
General
glycoprotein
kallikrein
Properties
SIZE: MW = 32 kD
entity length = 293 aa
COMPARTMENT: plasma
MOTIF: N-glycosylation site {N69}
cysteine residue {C73}
MODIFICATION: cysteine residue {C206}
cysteine residue {C93}
MODIFICATION: cysteine residue {C109}
histidine residue {H108}
cysteine residue {C109}
MODIFICATION: cysteine residue {C93}
aspartate residue {D153}
N-glycosylation site {N173}
cysteine residue {C178}
MODIFICATION: cysteine residue {C279}
cysteine residue {C185}
MODIFICATION: cysteine residue {C251}
cysteine residue {C206}
MODIFICATION: cysteine residue {C73}
N-glycosylation site {N208}
cysteine residue {C217}
MODIFICATION: cysteine residue {C231}
cysteine residue {C231}
MODIFICATION: cysteine residue {C217}
cysteine residue {C241}
MODIFICATION: cysteine residue {C266}
serine residue {S245}
cysteine residue {C251}
MODIFICATION: cysteine residue {C185}
N-glycosylation site {N252}
cysteine residue {C266}
MODIFICATION: cysteine residue {C241}
cysteine residue {C279}
MODIFICATION: cysteine residue {C178}
Database Correlations
OMIM 605643
UniProt Q9Y337
Entrez Gene 25818
References
- UniProt :accession Q9Y337
- Entrez Gene :accession 25818
- Yamasaki K, Di Nardo A, Bardan A, Murakami M, Ohtake T, Coda A,
Dorschner RA, Bonnart C, Descargues P, Hovnanian A, Morhenn VB,
Gallo RL.
Increased serine protease activity and cathelicidin promotes
skin inflammation in rosacea.
Nat Med. 2007 Aug;13(8):975-80. Epub 2007 Aug 5.
PMID: 17676051