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kallikrein-4; enamel matrix serine proteinase 1; kallikrein-like protein 1; KLK-L1; prostase; serine protease 17 (KLK4, EMSP1, PRSS17, PSTS)
Structure:
- belongs to the peptidase S1 family, kallikrein subfamily
- contains 1 peptidase S1 domain
Compartment: secreted
Expression: expressed in prostate
Pathology:
- defects in KLK4 are the cause of amelogenesis imperfecta, hypomaturation type, 2A1
General
glycoprotein
kallikrein
Properties
SIZE: entity length = 254 aa
MW = 27 kD
COMPARTMENT: plasma
MOTIF: signal sequence {1-26}
S1 domain {31-252}
MOTIF: cysteine residue {C37}
MODIFICATION: cysteine residue {C167}
Zn+2-binding site
SITE: 40-40
cysteine residue {C56}
MODIFICATION: cysteine residue {C72}
histidine residue {H71}
cysteine residue {C72}
MODIFICATION: cysteine residue {C56}
Zn+2-binding site
SITE: 91-91
aspartate residue {D116}
cysteine residue {C141}
MODIFICATION: cysteine residue {C241}
cysteine residue {C148}
MODIFICATION: cysteine residue {C213}
cysteine residue {C167}
MODIFICATION: cysteine residue {C37}
N-glycosylation site {N169}
cysteine residue {C178}
MODIFICATION: cysteine residue {C192}
cysteine residue {C192}
MODIFICATION: cysteine residue {C178}
cysteine residue {C203}
MODIFICATION: cysteine residue {C228}
serine residue {S207}
cysteine residue {C213}
MODIFICATION: cysteine residue {C148}
cysteine residue {C228}
MODIFICATION: cysteine residue {C203}
cysteine residue {C241}
MODIFICATION: cysteine residue {C141}
Database Correlations
OMIM correlations
MORBIDMAP 603767
UniProt Q9Y5K2
Pfam PF00089
Entrez Gene 9622
Kegg hsa:9622
References
- UniProt :accession Q9Y5K2
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org//genes/KLK4ID41084ch19q13.html