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kallikrein-15; ACO protease (KLK15)
Function:
- protease, physiological substrate unknown
Structure:
- belongs to the peptidase S1 family, kallikrein subfamily
- contains 1 peptidase S1 domain
Compartment: secreted (probable)
Alternative splicing:
- named isoforms=4
- at least one isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay
Expression:
- highest expression in thyroid gland
- also expressed in prostate, salivary glands, adrenal glands, colon, testis & kidney
General
glycoprotein
kallikrein
Properties
SIZE: entity length = 256 aa
MW = 28 kD
COMPARTMENT: plasma
MOTIF: signal sequence {1-16}
S1 domain {22-254}
MOTIF: cysteine residue {C47}
MODIFICATION: cysteine residue {C63}
histidine residue {H62}
cysteine residue {C63}
MODIFICATION: cysteine residue {C47}
aspartate residue {D106}
cysteine residue {C138}
MODIFICATION: cysteine residue {C215}
N-glycosylation site {N171}
cysteine residue {C180}
MODIFICATION: cysteine residue {C194}
cysteine residue {C194}
MODIFICATION: cysteine residue {C180}
cysteine residue {C205}
MODIFICATION: cysteine residue {C230}
serine residue {S209}
cysteine residue {C215}
MODIFICATION: cysteine residue {C138}
cysteine residue {C230}
MODIFICATION: cysteine residue {C205}
N-glycosylation site {N232}
Database Correlations
OMIM 610601
UniProt Q9H2R5
Pfam PF00089
Entrez Gene 55554
Kegg hsa:55554
References
- UniProt :accession Q9H2R5
- Entrez Gene :accession 55554