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kallikrein-11; hK11; hippostasin; serine protease 20; trypsin-like protease; contains: kallikrein-11 inactive chain 1 & kallikrein-11 inactive chain 2 (KLK11, PRSS20, TLSP, UNQ649/PRO1279)
Function:
- possible multifunctional protease
- efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, & weakly cleaves other substrates for kallikrein & trypsin
- cleaves synthetic peptides after Arg but not Lys
- about 40% of KLK11 is inactivated by internal cleavage after Arg-188 (may be effected by plasminogen)
Structure:
- belongs to the peptidase S1 family, kallikrein subfamily
- contains 1 peptidase S1 domain
Compartment: secreted
Alternative splicing: named isoforms=2
Expression:
- expressed in brain, skin & prostate
- isoform 1 is expressed preferentially in brain
- isoform 2 is expressed in prostate
- present in seminal plasma at concentrations ranging from 2 -37 ug/mL (at protein level)
General
glycoprotein
kallikrein
Properties
SIZE: entity length = 282 aa
MW = 31 kD
COMPARTMENT: plasma
MOTIF: signal sequence {1-50}
S1 domain {53-280}
MOTIF: cysteine residue {C60}
MODIFICATION: cysteine residue {C195}
cysteine residue {C79}
MODIFICATION: cysteine residue {C95}
histidine residue {H94}
cysteine residue {C95}
MODIFICATION: cysteine residue {C79}
N-glycosylation site {N131}
aspartate residue {D142}
cysteine residue {C167}
MODIFICATION: cysteine residue {C269}
cysteine residue {C174}
MODIFICATION: cysteine residue {C241}
cysteine residue {C195}
MODIFICATION: cysteine residue {C60}
N-glycosylation site {N197}
cysteine residue {C206}
MODIFICATION: cysteine residue {C220}
N-glycosylation site {N213}
cysteine residue {C220}
MODIFICATION: cysteine residue {C206}
cysteine residue {C231}
MODIFICATION: cysteine residue {C256}
serine residue {S235}
cysteine residue {C241}
MODIFICATION: cysteine residue {C174}
N-glycosylation site {N242}
cysteine residue {C256}
MODIFICATION: cysteine residue {C231}
cysteine residue {C269}
MODIFICATION: cysteine residue {C167}
Database Correlations
OMIM 604434
UniProt Q9UBX7
Pfam PF00089
Entrez Gene 11012
Kegg hsa:11012
References
- UniProt :accession Q9UBX7
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org//genes/KLK11ID41077ch19q13.html