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kallikrein-10; normal epithelial cell-specific 1; protease serine-like 1 (KLK10, NES1, PRSSL1)
Function:
- tumor-suppressor role for NES1 in breast cancer & prostate cancer
Structure:
- belongs to the peptidase S1 family, kallikrein subfamily
- contains 1 peptidase S1 domain
Compartment: secreted (probable)
Expression:
- expressed in breast, ovary & prostate
Pathology:
- down-regulated during breast cancer progression
General
anti-oncoprotein (tumor suppressor protein)
glycoprotein
kallikrein
Properties
SIZE: entity length = 276 aa
MW = 30 kD
COMPARTMENT: plasma
MOTIF: signal sequence {1-30}
N-glycosylation site {N39}
S1 domain {47-274}
MOTIF: cysteine residue {C52}
MODIFICATION: cysteine residue {C162}
cysteine residue {C71}
MODIFICATION: cysteine residue {C87}
histidine residue {H86}
cysteine residue {C87}
MODIFICATION: cysteine residue {C71}
aspartate residue {D137}
cysteine residue {C162}
MODIFICATION: cysteine residue {C52}
cysteine residue {C169}
MODIFICATION: cysteine residue {C235}
cysteine residue {C201}
MODIFICATION: cysteine residue {C215}
cysteine residue {C215}
MODIFICATION: cysteine residue {C201}
cysteine residue {C225}
MODIFICATION: cysteine residue {C250}
serine residue {S229}
cysteine residue {C235}
MODIFICATION: cysteine residue {C169}
cysteine residue {C250}
MODIFICATION: cysteine residue {C225}
Database Correlations
OMIM 602673
UniProt O43240
Pfam PF00089
Entrez Gene 5655
Kegg hsa:5655
References
- UniProt :accession O43240
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/KLK10ID41076ch19q13.html