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kainate receptor
Function:
- postsynaptic receptor for excitatory neurotransmitter L-glutamate in the central nervous system
- some variants of kainate receptors are somewhat permeable to Ca+2
- in some cases may behave as a metabotropic receptor [5]
Structure:
- homo or heterotetramer
Compartment:
- post-synpatic membrane
- some receptors may be presynaptic [5]
Genetics:
- 3 of 5 kainate receptor subunits are formed after mRNA editing
- kainate 1 receptor (GRIK1)
- kainate 2 receptor (GRIK2)
- kainate 3 receptor (GRIK3)
Interactions
molecular events
General
Ca+2 channel
ionotropic glutamate receptor
multisubunit protein
Na+ channel
Properties
COMPARTMENT: post synaptic membrane
CELL-REGION: dendrite
CELL: neuron
ION-PERMEABILITY: Na+
K+
SUBUNITS: glutamate receptor beta
MOTIF: exoplasmic domain {N-TERMINAL}
MOTIF: cysteine residue {C1}
MODIFICATION: cysteine residue {C2}
cysteine residue {C2}
MODIFICATION: cysteine residue {C1}
glycosylation site {N-TERMINAL}
ligand-binding site
exoplasmic loop
transmembrane domain {TM1}
transmembrane domain {TM2}
transmembrane domain {TM3}
cytoplasmic loop
LOOP#: 1
cytoplasmic domain {C-TERMINAL}
MOTIF: hydrophobic region
glutamate receptor gamma
MOTIF: exoplasmic domain {N-TERMINAL}
MOTIF: cysteine residue {C1}
MODIFICATION: cysteine residue {C2}
cysteine residue {C2}
MODIFICATION: cysteine residue {C1}
glycosylation site {N-TERMINAL}
ligand-binding site
exoplasmic loop
transmembrane domain {TM1}
transmembrane domain {TM2}
transmembrane domain {TM3}
cytoplasmic loop
LOOP#: 1
cytoplasmic domain {C-TERMINAL}
MOTIF: hydrophobic region
MISC-INFO: CONDUCTANCE 20 PS
LIGAND = KAINIC_ACID
LIGAND = GLUTAMATE
References
- Choi 1988
- Kutsuwada T, Kashiwabuchi N, Mori H, Sakimura K, Kushiya E,
Araki K, Meguro H, Masaki H, Kumanishi T, Arakawa M, et al.
Molecular diversity of the NMDA receptor channel.
Nature. 1992 Jul 2;358(6381):36-41.
PMID: 1377365
- Barnard EA.
Receptor classes and the transmitter-gated ion channels.
Trends Biochem Sci. 1992 Oct;17(10):368-74. Review.
PMID: 1360717
- Lipton SA, Rosenberg PA.
Excitatory amino acids as a final common pathway for neurologic
disorders.
N Engl J Med. 1994 Mar 3;330(9):613-22. Review.
PMID: 7905600
- Rodriguez-Moreno A, Sihra TS.
Metabotropic actions of kainate receptors in the CNS.
J Neurochem. 2007 Dec;103(6):2121-35. Epub 2007 Sep 20. Review.
PMID: 18070252
Components
glutamate receptor beta
glutamate receptor gamma