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K+ voltage-gated channel subfamily C member 2 (voltage-gated K+ channel Kv3.2, KCNC2)
Function:
- mediates the voltage-dependent K+ permeability of excitable membranes
- forms a K+-selective channel through which K+ may pass in accordance with their electrochemical gradient
- channel properties are modulated by subunit assembly (putative)
- the K+ channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits that can associate with modulating accessory subunits
- interacts with KCNC1, KCNE1, KCNE2 & KCNE3 (putative)
Structure:
- segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
- tail may be important in modulation of channel activity &/or targeting of the channel to specific subcellular compartments
- belongs to the K+ channel family, C (Shaw) subfamily
Compartment: membrane
Alternative splicing: named isoforms=4
General
glycoprotein
K+ channel subfamily C
transmembrane 6 protein
Properties
SIZE: entity length = 638 aa
MW = 70 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-229}
MOTIF: proline-rich region
SITE: 56-99
MOTIF: proline residue (SEVERAL)
transmembrane domain {230-250}
exoplasmic loop {251-283}
MOTIF: N-glycosylation site {N259}
N-glycosylation site {N266}
transmembrane domain {284-303}
cytoplasmic loop {304-313}
transmembrane domain {314-334}
exoplasmic loop {335-345}
transmembrane domain {346-368}
cytoplasmic loop {369-381}
transmembrane domain {382-402}
exoplasmic loop {403-452}
MOTIF: Selectivity filter {437-442}
transmembrane domain {453-473}
cytoplasmic domain {474-638}
ION-PERMEABILITY: K+
Database Correlations
OMIM 176256
UniProt Q96PR1
PFAM correlations
References
UniProt :accession Q96PR1