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K+ voltage-gated channel subfamily A member 7 (voltage-gated K+ channel subunit Kv1.7, KCNA7)
Function:
- mediates the voltage-dependent K+ permeability of excitable membranes
- K+-selective channel through which K+ ions may pass in accordance with their electrochemical gradient (putative)
- heterotetramer of K+ channel proteins
Structure:
- N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity &/or targeting of the channel to specific subcellular compartments (putative)
- segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position (putative)
- belongs to the K+ channel family, A (Shaker) subfamily
Compartment: membrane
Expression: highly expressed in skeletal muscle, heart & kidney
General
glycoprotein
K+ channel subfamily A (Shaker)
Properties
SIZE: entity length = 456 aa
MW = 51 kD
COMPARTMENT: plasma membrane
MOTIF: transmembrane domain {144-164}
N-glycosylation site {N191}
transmembrane domain {209-229}
cysteine residue {C231}
MODIFICATION: palmitate
COMPARTMENT: membrane
transmembrane domain {241-261}
transmembrane domain {276-295}
transmembrane domain {312-332}
Selectivity filter {358-363}
transmembrane domain {373-393}
ION-PERMEABILITY: K+
Database Correlations
OMIM 176268
UniProt Q96RP8
PFAM correlations
References
UniProt :accession Q96RP8