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K+ voltage-gated channel subfamily A member 10 (voltage-gated K+ channel subunit Kv1.8, KCNA10)
Function:
- mediates voltage-dependent K+ permeability of excitable membranes
- opened or closed conformations in response to voltage difference across the membrane
- K+-selective channel through which K+ may pass in accordance with electrochemical gradient
- channel activity is up-regulated by cAMP
- homotetramer
- interaction with KCN4B/POMP is necessary for modulation of channel activity by cAMP
Structure:
- N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity &/or targeting of the channel tospecific subcellular compartments
- segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
- belongs to the K+ channel family, A (Shaker) subfamily
Compartment: membrane
Expression:
- detected in kidney, in proximal tubules, glomerular endothelium, in vascular endothelium & in smooth muscle cells
General
glycoprotein
voltage-gated K+ channel alpha subunit
Properties
SIZE: entity length = 511 aa
MW = 58 kD
COMPARTMENT: plasma membrane
MOTIF: transmembrane domain {218-238}
N-glycosylation site {N256}
transmembrane domain {271-292}
cysteine residue {C293}
MODIFICATION: palmitate
COMPARTMENT: membrane
transmembrane domain {303-323}
N-glycosylation site {N334}
transmembrane domain {339-358}
transmembrane domain {375-395}
Selectivity filter {421-426}
transmembrane domain {436-456}
N-glycosylation site {N498}
ION-PERMEABILITY: K+
Database Correlations
OMIM 602420
UniProt Q16322
PFAM correlations
References
UniProt :accession Q16322