K+ channel tetramerization domain containing protein 13; BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1; hBACURD1; BTB/POZ domain-containing protein KCTD13; polymerase delta-interacting protein 1; TNFAIP1-like protein (KCTD13, BACURD1, PDIP1, POLDIP1, FKSG86, PP6832)

Function: - substrate-specific adapter of BCR E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure - protein modification; protein ubiquitination - component of the BCR(BACURD1) E3 ubiquitin ligase complex - interacts with RHOA; with a preferrence for RhoA-GDP - interacts with DNA polymerase delta (POLD2) & PCNA Structure: - belongs to the BACURD family - contains 1 BTB/POZ domain Compartment: nucleus Expression: - expressed in a wide variety of tissues - induced by TNF & IL6

Properties

SIZE: MW = 36 kD entity length = 329 aa COMPARTMENT: cell nucleus MOTIF: BTB domain {41-109} MOTIF: Zinc finger NAME: Zinc finger EFFECTOR-BOUND: Zn+2

Database Correlations

OMIM 608947 UniProt Q8WZ19 Pfam PF02214 Entrez Gene 253980 Kegg hsa:253980

References

UniProt :accession Q8WZ19