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K+ channel subfamily T member 2 (sequence like an intermediate conductance K+ channel subunit, Na+ & chloride-activated ATP-sensitive K+ channel Slo2.1, KCNT2, SLICK)
Function:
- outward rectifying K+ channel
- produces rapidly activating outward rectifier K(+) currents
- activated by high intracellular Na+ & Cl- levels
- channel activity is inhibited by ATP & by inhalation anesthetics, including as isoflurane
- inhibited upon stimulation of G-protein coupled receptors, including as CHRM1 & GRIA1
- phosphorylated by protein kinase C
- phosphorylation of the C-terminal domain inhibits channel activity
Structure:
- belongs to the K+ channel family
- Ca+2-activated subfamily
- contains 1 RCK N-terminal domain
Compartment: cell membrane
Alternative splicing: named isoforms=4
General
glycoprotein
K+ channel subfamily T
membrane protein
transmembrane 6 protein
Properties
SIZE: entity length = 1135 aa
MW = 131 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-63}
transmembrane domain {64-84}
exoplasmic loop {85-101}
MOTIF: N-glycosylation site {N99}
transmembrane domain {102-122}
cytoplasmic loop {123-137}
transmembrane domain {138-158}
exoplasmic loop {159-164}
transmembrane domain {165-185}
cytoplasmic loop {186-198}
transmembrane domain {199-219}
exoplasmic loop {220-256}
MOTIF: Pore-forming, in membrane {229-249}
transmembrane domain {257-277}
cytoplasmic domain {278-1135}
MOTIF: RCK N-terminal {422-543}
ATP-binding site
NAME: ATP-binding site
SITE: 1025-1032
ION-PERMEABILITY: K+
Database Correlations
UniProt Q6UVM3
PFAM correlations
References
UniProt :accession Q6UVM3