K+ channel subfamily K member 7 (KCNK7)

Function: - probable K⁺ channel subunit - no channel activity - observed in vitro as protein remains in endoplasmic reticulum - may need to associate with an as yet unknown partner in order to reach the plasma membrane Structure: - homodimer (putative) - belongs to the two pore domain K⁺ channel (TC 1.A.1.8) family Compartment: membrane (potential) Alternative splicing: named isoforms=3; A, B, C

General

glycoprotein K+ channel subfamily K transmembrane 4 protein

Properties

SIZE: entity length = 307 aa MW = 32 kD COMPARTMENT: plasma membrane MOTIF: cytoplasmic domain {1-10} transmembrane domain {11-31} exoplasmic loop {32-119} MOTIF: N-glycosylation site {N83} Pore-forming 1 {92-119} transmembrane domain {120-140} cytoplasmic loop {141-170} transmembrane domain {171-191} exoplasmic loop {192-232} MOTIF: Pore-forming 2 {199-227} transmembrane domain {233-253} cytoplasmic domain {254-307} ION-PERMEABILITY: K+

Database Correlations

OMIM 603940 UniProt Q9Y2U2 Pfam PF07885 Entrez Gene 10089 Kegg hsa:10089