Search
K+ channel subfamily K member 6; inward rectifying K+ channel protein TWIK-2; TWIK-originated similarity sequence (KCNK6, TOSS, TWIK2)
Function:
- outward rectification with physiological K+ gradient
- mild inward rectification with symmetrical K+ conditions
Structure:
- homodimer (putative)
- belongs to the two pore domain K+ channel (TC 1.A.1.8) family
Compartment: membrane (potential)
Alternative splicing: named isoforms=2
Expression:
- widespread expression
- detected in all tissues tested except for skeletal muscle
- strongest expression in placenta, pancreas, heart, colon & spleen
- lower levels in peripheral blood leukocytes, lung, liver, kidney & thymus
- lowest expression in brain
Notes:
- inhibited by internal acidification &, to a small degree, by Zn+2
- not inhibited by quinine, quinidine or Ba+2
General
glycoprotein
K+ channel subfamily K
transmembrane 4 protein
Properties
SIZE: entity length = 313 aa
MW = 34 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-4}
transmembrane domain {5-25}
exoplasmic loop {26-120}
MOTIF: N-glycosylation site {N79}
N-glycosylation site {N85}
Pore-forming 1 {90-115}
transmembrane domain {121-141}
cytoplasmic loop {142-172}
transmembrane domain {173-193}
exoplasmic loop {194-235}
MOTIF: Pore-forming 2 {199-223}
transmembrane domain {236-256}
cytoplasmic domain {257-313}
ION-PERMEABILITY: K+
Database Correlations
OMIM 603939
UniProt Q9Y257
Pfam PF07885
Entrez Gene 9424
Kegg hsa:9424
References
UniProt :accession Q9Y257
OMIM :accession Q9Y257