Search
K+ channel subfamily K member 5; acid-sensitive K+ channel protein TASK-2; TWIK-related acid-sensitive K+ channel 2 (KCNK5, TASK2)
Function:
- pH-dependent, voltage insensitive, outwardly rectifying K+ channel
- outward rectification is lost at high external K+ concentrations
Structure:
- homodimer; disulfide-linked
- belongs to the two pore domain K+ channel (TC 1.A.1.8) family
Compartment: membrane (potential)
Expression:
- abundant expression in kidney
- also detected in liver, placenta & small intestine
- in kidney, expression is restricted to the distal tubules & collecting ducts
- not expressed in proximal tubules or glomeruli
Notes:
- inhibited by quinine, quinidine & external acidification
General
glycoprotein
K+ channel subfamily K
phosphoprotein
transmembrane 4 protein
Properties
SIZE: entity length = 499 aa
MW = 55 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-7}
transmembrane domain {8-26}
exoplasmic loop {27-112}
MOTIF: cysteine residue {C51}
MODIFICATION: cysteine residue {C-INTERCHAIN}
N-glycosylation site {N77}
Pore-forming 1 {85-112}
transmembrane domain {113-133}
cytoplasmic loop {134-157}
transmembrane domain {158-180}
exoplasmic loop {181-229}
MOTIF: Pore-forming 2 {190-215}
transmembrane domain {230-250}
cytoplasmic domain {251-325}
Ser phosphorylation site {S371}
ION-PERMEABILITY: K+
Database Correlations
OMIM 603493
UniProt O95279
Pfam PF07885
Entrez Gene 8645
Kegg hsa:8645
References
- UniProt :accession O95279
- OMIM :accession O95279