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K+ channel subfamily K member 4; TWIK-related arachidonic acid-stimulated K+ channel protein; TRAAK; two pore K+ channel KT4.1 (KCNK4, TRAAK)
Function:
- voltage insensitive, instantaneous, outwardly rectifying K+ channel
- outward rectification is reversed at high external K+ concentrations (putative)
Structure:
- homodimer (putative)
- belongs to the two pore domain K+ channel (TC 1.A.1.8) family
Compartment: membrane (potential)
Alternative splicing: named isoforms=2
Note:
- at lease one isoform may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay
General
glycoprotein
K+ channel subfamily K
transmembrane 4 protein
Properties
SIZE: entity length = 393 aa
MW = 43 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-3}
transmembrane domain {4-24}
exoplasmic loop {25-117}
MOTIF: N-glycosylation site {N78}
N-glycosylation site {N82}
Pore-forming 1 {89-113}
transmembrane domain {118-138}
cytoplasmic loop {139-171}
transmembrane domain {172-192}
exoplasmic loop {193-233}
MOTIF: Pore-forming 2 {197-221}
transmembrane domain {234-254}
cytoplasmic domain {255-393}
ION-PERMEABILITY: K+
Database Correlations
OMIM 605720
UniProt Q9NYG8
Pfam PF07885
Entrez Gene 50801
Kegg hsa:50801
References
- UniProt :accession Q9NYG8
- OMIM :accession Q9NYG8