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K+ channel subfamily K member 3; acid-sensitive K+ channel protein TASK-1; TWIK-related acid-sensitive K+ channel 1; Two pore K+ channel KT3.1 (KCNK3, TASK, TASK1)
Function:
- pH-dependent, voltage-insensitive, background K+ channel protein
- rectification direction results from K+ ion concentration on either side of the membrane
- acts as an outward rectifier when external K+ concentration is low
- when external K+ concentration is high, current is inward
Structure:
- belongs to the two pore domain K+ channel (TC 1.A.1.8) family
Compartment: membrane (potential)
Expression:
- widespread expression in adult
- strongest expression in pancreas & placenta
- lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine & colon
Notes:
- inhibited by external acidification
- activated by halothane & isoflurane
General
glycoprotein
K+ channel subfamily K
transmembrane 4 protein
Properties
SIZE: entity length = 394 aa
MW = 44 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-8}
transmembrane domain {9-29}
exoplasmic loop {30-107}
MOTIF: N-glycosylation site {N53}
Pore-forming 1 {78-101}
transmembrane domain {108-128}
cytoplasmic loop {129-158}
transmembrane domain {159-179}
exoplasmic loop {180-222}
MOTIF: Pore-forming 2 {184-207}
transmembrane domain {223-243}
cytoplasmic domain {244-394}
ION-PERMEABILITY: K+
Database Correlations
OMIM 603220
UniProt O14649
Pfam PF07885
Entrez Gene 3777
Kegg hsa:3777
References
- UniProt :accession O14649
- OMIM :accession O14649