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K+ channel subfamily K member 2; outward rectifying K+ channel protein TREK-1; TREK-1 K+ channel subunit; Two pore K+ channel TPKC1; two pore domain K+ channel TREK-1 (KCNK2, TREK, TREK1)
Function:
- outwardly-rectifying K+ channel
Structure:
- homodimer (putative)
- belongs to the two pore domain K+ channel (TC 1.A.1.8) family
Compartment: membrane (potential)
Alternative splicing: named isoforms=3
Pharmacology:
- activated by volatile general anesthetics such as chloroform, halothane & isoflurane
General
glycoprotein
K+ channel subfamily K
transmembrane 4 protein
Properties
SIZE: entity length = 426 aa
MW = 47 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-61}
transmembrane domain {62-82}
exoplasmic loop {83-171}
MOTIF: N-glycosylation site {N110}
N-glycosylation site {N134}
Pore-forming 1 {144-170}
transmembrane domain {172-192}
cytoplasmic loop {193-223}
transmembrane domain {224-244}
exoplasmic loop {245-287}
MOTIF: Pore-forming 2 {253-283}
transmembrane domain {288-308}
cytoplasmic domain {309-426}
MOTIF: basal channel activity {354-426}
anesthetic {378-426}
ION-PERMEABILITY: K+
Database Correlations
OMIM 603219
UniProt O95069
Pfam PF07885
Entrez Gene 3776
Kegg hsa:3776
References
- UniProt :accession O95069
- OMIM :accession O95069