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K+ channel subfamily K member 18 (TWIK-related individual K+ channel, TWIK-related spinal cord K+ channel, KCNK18, TRESK, TRIK)
Function:
- outward rectifying K+ channel
- produces rapidly activating outward rectifier K(+) currents
- may function as background K+ channel that sets the resting membrane potential
- inhibited by arachidonic acid & other naturally occurring unsaturated free fatty acids
- channel activity is enhanced by volatile anesthetics, including as isoflurane
Structure:
- belongs to the two pore domain K+ channel (TC 1.A.1.8) family
Compartment: membrane
Expression: detected at low levels in spinal cord
General
glycoprotein
K+ channel subfamily K
phosphoprotein
transmembrane 6 protein
Properties
SIZE: entity length = 384 aa
MW = 44 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-23}
transmembrane domain {24-44}
exoplasmic loop {45-102}
MOTIF: N-glycosylation site {N70}
N-glycosylation site {N96}
transmembrane domain {103-123}
cytoplasmic loop {124-127}
MOTIF: Pore-forming 1 {103-129}
transmembrane domain {128-148}
exoplasmic loop {149-280}
MOTIF: calcineurin interaction {200-205}
Ser phosphorylation site {S264}
transmembrane domain {281-301}
cytoplasmic loop {302-312}
transmembrane domain {313-333}
MOTIF: Pore-forming 2 {314-328}
exoplasmic loop {334-334}
transmembrane domain {335-355}
cytoplasmic domain {356-384}
ION-PERMEABILITY: K+
Database Correlations
UniProt Q7Z418
Pfam PF07885
References
UniProt :accession Q7Z418