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K+ channel subfamily K member 17; TWIK-related alkaline pH-activated K+ channel 2; 2P domain K+ channel Talk-2; TWIK-related acid-sensitive K+ channel 4; TASK-4 (KCNK17 TALK2, TASK4, UNQ5816/PRO19634)
Function:
- outwardly-rectifying K+ channel
- produces rapidly activating & non-inactivating outward rectifier K+ currents
Structure:
- homodimer (putative)
- belongs to the two pore domain K+ channel (TC 1.A.1.8) family
Compartment: membrane
Notes:
- inhibited by Ba+2, quinidine, chloroform & halothane
- activated at alkaline pH
- activated by quinine & isoflurane
General
glycoprotein
K+ channel subfamily K
transmembrane 4 protein
Properties
SIZE: entity length = 332 aa
MW = 37 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-20}
transmembrane domain {21-43}
exoplasmic loop {44-127}
MOTIF: N-glycosylation site {N65}
N-glycosylation site {N94}
Pore-forming 1 {106-124}
transmembrane domain {128-148}
cytoplasmic loop {149-179}
transmembrane domain {180-200}
exoplasmic loop {201-243}
MOTIF: Pore-forming 2 {211-230}
transmembrane domain {244-264}
cytoplasmic domain {265-332}
ION-PERMEABILITY: K+
Database Correlations
OMIM 607370
UniProt Q96T54
Pfam PF07885
Entrez Gene 89822
Kegg hsa:89822
References
UniProt :accession Q96T54