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K+ channel subfamily K member 13 (tandem pore domain halothane inhibited potassium channel 1, THIK-1, KCNK13)
Function:
- K+ channel with weak inward rectification in symmetrical K+ solution (putative)
Structure:
- homodimer (putative)
- belongs to the two pore domain K+ channel (TC 1.A.1.8) family
Compartment: membrane (potential)
Notes:
- current is enhanced by arachidonic acid & inhibited by halothane (putative)
General
glycoprotein
K+ channel subfamily K
transmembrane 6 protein
Properties
SIZE: MW = 45 kD
entity length = 408 aa
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-19}
transmembrane domain {20-40}
exoplasmic loop {41-94}
MOTIF: N-glycosylation site {N59}
N-glycosylation site {N65}
transmembrane domain {95-115}
cytoplasmic loop {116-124}
transmembrane domain {125-145}
exoplasmic loop {146-193}
transmembrane domain {194-214}
cytoplasmic loop {215-223}
transmembrane domain {224-244}
exoplasmic loop {245-262}
transmembrane domain {263-283}
cytoplasmic domain {284-408}
ION-PERMEABILITY: K+
Database Correlations
OMIM 607367
UniProt Q9HB14
Pfam PF07885
Entrez Gene 56659
Kegg hsa:56659
References
UniProt :accession Q9HB14