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K+ channel subfamily K member 10; outward rectifying K+ channel protein TREK-2; TREK-2 K+ channel subunit (KCNK10, TREK2)
Function:
- outwardly-rectifying K+ channel
- produces rapidly activating & non-inactivating outward rectifier K+ currents
- activated by arachidonic acid & other naturally occurring unsaturated free fatty acids
Structure:
- belongs to the two pore domain K+ channel (TC 1.A.1.8) family
Compartment:
- membrane (potential)
Alternative splicing: named isoforms=3; A, B, C
Expression:
- abundantly expressed in pancreas & kidney
- expressed to a lower level in brain, testis, colon, & small intestine
- isoform B is strongly expressed in kidney (primarily in the proximal tubule) & pancreas
- isoform C is abundantly expressed in brain
General
glycoprotein
K+ channel subfamily K
transmembrane 4 protein
Properties
SIZE: entity length = 538 aa
MW = 60 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-71}
transmembrane domain {72-92}
exoplasmic loop {93-181}
MOTIF: N-glycosylation site {N144}
N-glycosylation site {N147}
N-glycosylation site {N148}
Pore-forming 1 {154-180}
transmembrane domain {182-202}
cytoplasmic loop {203-233}
transmembrane domain {234-254}
exoplasmic loop {255-298}
MOTIF: Pore-forming 2 {263-294}
transmembrane domain {299-319}
cytoplasmic domain {320-538}
ION-PERMEABILITY: K+
Database Correlations
OMIM 605873
UniProt P57789
Pfam PF07885
Entrez Gene 54207
Kegg hsa:54207
References
- UniProt :accession P57789
- OMIM :accession P57789