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K+ channel subfamily K member 1; Inward rectifying K+ channel protein TWIK-1; K+ channel KCNO1 (KCNK1, HOHO1, KCNO1 TWIK1)
Function:
- weak inwardly-rectifying K+ channel
- activated by protein kinase C
Structure:
- homodimer (putative)
- belongs to the two pore domain K+ channel (TC 1.A.1.8) family
Compartment: membrane (potential)
Expression:
- widely expressed
- high levels in heart & brain
- lower levels in placenta, lung, liver & kidney
Notes:
- inhibited by Ba+2, quinine, quinidine & internal acidification
General
glycoprotein
K+ channel subfamily K
phosphoprotein
transmembrane 4 protein
Properties
SIZE: entity length = 336 aa
MW = 38 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-20}
transmembrane domain {21-41}
exoplasmic loop {42-132}
MOTIF: N-glycosylation site {N95}
Pore-forming 1 {104-130}
transmembrane domain {133-153}
cytoplasmic loop {154-177}
transmembrane domain {178-198}
exoplasmic loop {199-246}
MOTIF: Pore-forming 2 {212-238}
transmembrane domain {247-267}
cytoplasmic domain {268-336}
MOTIF: Ser phosphorylation site {S326}
ION-PERMEABILITY: K+
Database Correlations
OMIM 601745
UniProt O00180
Pfam PF07885
Entrez Gene 3775
Kegg hsa:3775
References
UniProt :accession O00180