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K+ voltage-gated channel subfamily H member 8; ELK1; hElk1; ether-a-go-go-like K+ channel 3; ELK channel 3; ELK3; voltage-gated K+ channel subunit Kv12.1 (KCNH8)
Function:
- pore-forming (alpha) subunit of voltage-gated K+ channel
- elicits a slowly activating, outward rectifying current
- channel properties may be modulated by cAMP & subunit assembly
- the K+ channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits
Structure:
- the segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
- belongs to the K+ channel family, H (Eag) (TC 1.A.1.20) subfamily, Kv12.1/KCNH8 sub-subfamily
- contains 1 cyclic nucleotide-binding domain
- contains 1 PAC (PAS-associated C-terminal) domain
- contains 1 PAS (PER-ARNT-SIM) domain
Compartment: membrane
Expression:
- primarily expressed in the nervous system
General
glycoprotein
K+ channel subfamily H
transmembrane 6 protein
Properties
SIZE: entity length = 1107 aa
MW = 124 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-225}
MOTIF: PAS domain {18-90}
PAC domain {93-145}
transmembrane domain {226-246}
exoplasmic loop {247-255}
transmembrane domain {256-276}
cytoplasmic loop {277-298}
transmembrane domain {299-319}
exoplasmic loop {320-327}
MOTIF: N-glycosylation site {N320}
transmembrane domain {328-348}
cytoplasmic loop {349-357}
transmembrane domain {358-378}
exoplasmic loop {379-419}
MOTIF: N-glycosylation site {N409}
Selectivity filter {434-439}
exoplasmic loop {441-448}
transmembrane domain {449-469}
cytoplasmic domain {470-1107}
MOTIF: cyclic nucleotide-binding site
SITE: 551-668
glutamate-rich region {711-723}
MOTIF: glutamate residue (SEVERAL)
serine-rich region {951-1064}
MOTIF: serine residue (SEVERAL)
ION-PERMEABILITY: K+
Database Correlations
OMIM 608260
UniProt Q96L42
PFAM correlations
Entrez Gene 131096
Kegg hsa:131096
References
UniProt :accession Q96L42