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K+ voltage-gated channel subfamily H member 7; ether-a-go-go-related gene K+ channel 3; ERG-3; Eag-related protein 3; ether-a-go-go-related protein 3; hERG-3; voltage-gated K+ channel subunit Kv11.3 (KCNH7, ERG3)
Function:
- pore-forming (alpha) subunit of voltage-gated K+ channel
- channel properties may be modulated by cAMP & subunit assembly
- the K+ channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits
- heteromultimer with KCNH2/ERG1 & KCNH6/ERG2 (putative)
Structure:
- the segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
- belongs to the K+ channel family, H (Eag) (TC 1.A.1.20) subfamily, Kv11.3/KCNH7 sub-subfamily
- contains 1 cyclic nucleotide-binding domain
- contains 1 PAC (PAS-associated C-terminal) domain
- contains 1 PAS (PER-ARNT-SIM) domain
Compartment: membrane
Alternative splicing: named isoforms=2
Expression:
- expressed in prolactin-secreting adenomas
General
glycoprotein
K+ channel subfamily H
transmembrane 6 protein
Properties
SIZE: entity length = 1196 aa
MW = 135 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-412}
MOTIF: PAS domain {41-70}
PAC domain {92-144}
Ser phosphorylation site {S349}
Ser phosphorylation site {S350}
Ser phosphorylation site {S353}
transmembrane domain {413-433}
exoplasmic loop {434-449}
transmembrane domain {450-470}
cytoplasmic loop {471-494}
transmembrane domain {495-515}
exoplasmic loop {516-521}
transmembrane domain {522-542}
cytoplasmic loop {543-549}
transmembrane domain {550-570}
exoplasmic loop {571-614}
MOTIF: N-glycosylation site {N600}
Selectivity filter {627-632}
exoplasmic loop {636-641}
transmembrane domain {642-662}
cytoplasmic domain {663-1196}
MOTIF: cyclic nucleotide-binding site
SITE: 745-862
ION-PERMEABILITY: K+
Database Correlations
OMIM 608169
UniProt Q9NS40
PFAM correlations
Entrez Gene 90134
Kegg hsa:90134
References
UniProt :accession Q9NS40