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K+ voltage-gated channel subfamily H member 6; ether-a-go-go-related gene K+ channel 2; ERG-2; Eag-related protein 2; ether-a-go-go-related protein 2; hERG-2; hERG2; voltage-gated K+ channel subunit Kv11.2 (KCNH6 ERG2)
Function:
- pore-forming (alpha) subunit of voltage-gated K+ channel
- elicits a slowly activating, rectifying current
- channel properties may be modulated by cAMP & subunit assembly
- the K+ channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits
- heteromultimers with KCNH2/ERG1 & KCNH7/ERG3 (putative)
Structure:
- the segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
- belongs to the K+ channel family, H (Eag) (TC 1.A.1.20) subfamily, Kv11.2/KCNH6 sub-subfamily
- contains 1 cyclic nucleotide-binding domain
- contains 1 PAC (PAS-associated C-terminal) domain
- contains 1 PAS (PER-ARNT-SIM) domain
Compartment: membrane
Alternative splicing: named isoforms=3
Expression:
- expressed in prolactin-secreting adenomas
General
glycoprotein
K+ channel subfamily H
transmembrane 6 protein
Properties
SIZE: entity length = 994 aa
MW = 110 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-261}
MOTIF: PAS domain {41-70}
PAC domain {92-144}
transmembrane domain {262-282}
exoplasmic loop {283-298}
transmembrane domain {299-319}
cytoplasmic loop {320-340}
transmembrane domain {341-361}
exoplasmic loop {362-370}
transmembrane domain {371-391}
cytoplasmic loop {392-398}
transmembrane domain {399-419}
exoplasmic loop {420-463}
Selectivity filter {476-481}
exoplasmic loop {485-490}
transmembrane domain {491-511}
cytoplasmic domain {512-994}
MOTIF: cyclic nucleotide-binding site
SITE: 594-711
ION-PERMEABILITY: K+
Database Correlations
OMIM 608168
UniProt Q9H252
PFAM correlations
Entrez Gene 81033
Kegg hsa:81033
References
UniProt :accession Q9H252