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K+ voltage-gated channel subfamily H member 5; ether-a-go-go K+ channel 2; hEAG2; voltage-gated K+ channel subunit Kv10.2 (KCNH5 EAG2)
Function:
- pore-forming (alpha) subunit of voltage-gated K+ channel
- elicits a non-inactivating outward rectifying current
- channel properties may be modulated by cAMP & subunit assembly
- the K+ channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits
- heteromultimer with KCNH1/EAG (probable)
Structure:
- the segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
- belongs to the K+ channel family, H (Eag) (TC 1.A.1.20) subfamily, Kv10.2/KCNH5 sub-subfamily
- contains 1 cyclic nucleotide-binding domain
- contains 1 PAC (PAS-associated C-terminal) domain
- contains 1 PAS (PER-ARNT-SIM) domain
Compartment: membrane
Alternative splicing: named isoforms=3
Expression:
- expressed in brain, skeletal muscle, heart, placenta, lung & liver
- expressed at low levels in kidney
General
glycoprotein
K+ channel subfamily H
transmembrane 6 protein
Properties
SIZE: entity length = 988 aa
MW = 112 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-217}
MOTIF: PAS domain {12-90}
PAC domain {91-143}
transmembrane domain {218-238}
exoplasmic loop {239-243}
transmembrane domain {244-264}
cytoplasmic loop {265-291}
transmembrane domain {292-312}
exoplasmic loop {313-319}
transmembrane domain {320-340}
cytoplasmic loop {341-346}
transmembrane domain {347-367}
exoplasmic loop {368-419}
MOTIF: N-glycosylation site {N403}
Selectivity filter {432-437}
exoplasmic loop {441-446}
transmembrane domain {447-467}
cytoplasmic domain {468-988}
MOTIF: cyclic nucleotide-binding site
SITE: 550-667
calmodulin binding site
SITE: 704-715
FOR-BINDING-OF: calmodulin
CAD {909-948}
ION-PERMEABILITY: K+
Database Correlations
OMIM 605716
UniProt Q8NCM2
PFAM correlations
Entrez Gene 27133
Kegg hsa:27133
References
UniProt :accession Q8NCM2