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K+ voltage-gated channel subfamily H member 3; brain-specific eag-like channel 1; BEC1; ether-a-go-go-like K+ channel 2; ELK channel 2; ELK2; voltage-gated K+ channel subunit Kv12.2 (KCNH3, KIAA1282)
Function:
- pore-forming (alpha) subunit of voltage-gated K+ channel
- elicits an outward current with fast inactivation
- channel properties may be modulated by cAMP & subunit assembly
- the K+ channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits
Structure:
- the segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
- belongs to the K+ channel family, H (Eag) (TC 1.A.1.20) subfamily, Kv12.2/KCNH3 sub-subfamily
- contains 1 cyclic nucleotide-binding domain
- contains 1 PAC (PAS-associated C-terminal) domain
- contains 1 PAS (PER-ARNT-SIM) domain
Compartment: membrane
Expression:
- detected only in brain, in particular in the telencephalon
- expressed in cerebral cortex, occipital pole, frontal lobe, temporal lobe, putamen, amygdala, hippocampus & caudate nucleus
General
glycoprotein
K+ channel subfamily H
transmembrane 6 protein
Properties
SIZE: entity length = 1083 aa
MW = 117 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-228}
MOTIF: PAS domain {18-90}
PAC domain {93-145}
transmembrane domain {229-249}
exoplasmic loop {250-259}
transmembrane domain {260-280}
cytoplasmic loop {281-302}
transmembrane domain {303-323}
exoplasmic loop {324-331}
transmembrane domain {332-352}
cytoplasmic loop {353-361}
transmembrane domain {362-382}
exoplasmic loop {383-453}
MOTIF: N-glycosylation site {N421}
N-glycosylation site {N428}
N-glycosylation site {N436}
Selectivity filter {465-470}
exoplasmic loop {475-479}
transmembrane domain {480-500}
cytoplasmic domain {501-1083}
MOTIF: cyclic nucleotide-binding site
SITE: 582-697
proline-rich region
SITE: 951-1057
MOTIF: proline residue (SEVERAL)
ION-PERMEABILITY: K+
Database Correlations
OMIM 604527
UniProt Q9ULD8
PFAM correlations
Entrez Gene 23416
Kegg hsa:23416
References
UniProt :accession Q9ULD8