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K+ voltage-gated channel subfamily H member 1; ether-a-go-go K+ channel 1; EAG channel 1; h-eag; hEAG1; voltage-gated K+ channel subunit Kv10.1 (KCNH1, EAG, EAG1)
Function:
- pore-forming (alpha) subunit of voltage-gated non- inactivating delayed rectifier K+ channel
- channel properties may be modulated by cAMP & subunit assembly
- mediates IK(NI) current in myoblasts
- the K+ channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits
- heteromultimer with KCNH5/EAG2
- interacts with ALG10B (putative)
Structure:
- the segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
- belongs to the K+ channel family, H (Eag) (TC 1.A.1.20) subfamily, Kv10.1/KCNH1 sub-subfamily
- contains 1 cyclic nucleotide-binding domain
- contains 1 PAC (PAS-associated C-terminal) domain
- contains 1 PAS (PER-ARNT-SIM) domain
Compartment: membrane
Alternative splicing: named isoforms=2
Expression:
- highly expressed in brain & in myoblasts at the onset of fusion
- not expressed in other tissues
- detected in HeLa (cervical carcinoma), SH-SY5Y (neuroblastoma) & MCF-7 (epithelial tumor) cells, but not in normal epithelial cells
General
glycoprotein
K+ channel subfamily H
transmembrane 6 protein
Properties
SIZE: entity length = 989 aa
MW = 111 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-220}
MOTIF: PAS domain {14-94}
PAC domain {93-145}
transmembrane domain {221-241}
exoplasmic loop {242-248}
transmembrane domain {249-269}
cytoplasmic loop {270-294}
transmembrane domain {295-315}
exoplasmic loop {316-349}
transmembrane domain {350-370}
cytoplasmic loop {371-376}
transmembrane domain {377-397}
exoplasmic loop {398-450}
MOTIF: N-glycosylation site {N415}
N-glycosylation site {N433}
Selectivity filter {463-468}
exoplasmic loop {472-477}
transmembrane domain {478-498}
cytoplasmic domain {499-989}
MOTIF: cyclic nucleotide-binding site
SITE: 581-698
calmodulin binding site
SITE: 673-770
FOR-BINDING-OF: calmodulin
CAD {924-964}
ION-PERMEABILITY: K+
Database Correlations
OMIM 603305
UniProt O95259
PFAM correlations
Entrez Gene 3756
Kegg hsa:3756
References
- UniProt :accession O95259
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/KCNH1ID41048ch1q32.html