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K+ voltage-gated channel subfamily F member 1; voltage-gated K+ channel subunit Kv5.1; kH1 (KCNF1)
Function:
- putative voltage-gated K+ channel
- heteromultimer with KCNG3, KCNG4 & KCNV2
- interacts with DLG1
Structure:
- the segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
- belongs to the K+ channel family, F (TC 1.A.1.2) subfamily, Kv5.1/KCNF1 sub-subfamily
Compartment: membrane
Expression:
- expressed in heart, brain, liver, skeletal muscle, kidney & pancreas
General
glycoprotein
K+ channel subfamily F
transmembrane 6 protein
Properties
SIZE: entity length = 494 aa
MW = 56 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-183}
transmembrane domain {184-204}
exoplasmic loop {205-223}
transmembrane domain {224-244}
cytoplasmic loop {245-249}
transmembrane domain {250-270}
exoplasmic loop {271-289}
transmembrane domain {290-310}
cytoplasmic loop {311-324}
transmembrane domain {325-345}
exoplasmic loop {346-385}
MOTIF: peptide motif {370-375}
transmembrane domain {386-406}
cytoplasmic domain {407-494}
ION-PERMEABILITY: K+
Database Correlations
OMIM 603787
UniProt Q9H3M0
PFAM correlations
Entrez Gene 3754
Kegg hsa:3754
References
UniProt :accession Q9H3M0