K+ voltage-gated channel subfamily E member 4; minK-related peptide 3; minimum K+ channel-related peptide 3; K+ channel subunit beta MiRP3 (KCNE4)

Function: - ancillary protein that assembles as a beta subunit with a voltage-gated K⁺ channel complex of pore-forming alpha subunits - modulates the gating kinetics & enhances stability of the channel complex - may associate with KCNQ1/KVLTQ1 & inhibit K⁺ current Structure: belongs to the K⁺ channel KCNE family Compartment: - membrane; single-pass type 1 membrane protein Expression: - predominantly expressed in embryo & adult uterus - low expression found in kidney, small intestine, lung & heart

General

glycoprotein K+ channel subfamily E

Properties

SIZE: entity length = 170 aa MW = 18 kD COMPARTMENT: cellular membrane MOTIF: N-glycosylation site {N8} transmembrane domain {36-56} ION-PERMEABILITY: K+

Database Correlations

OMIM 607775 UniProt Q8WWG9 Pfam PF02060 Entrez Gene 23704 Kegg hsa:23704

References

UniProt :accession Q8WWG9