K+ voltage-gated channel subfamily D member 2; voltage-gated K+ channel subunit Kv4.2 (KCND2, KIAA1044)

Function: - pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type K⁺ channels - may contribute to I(To) current in heart & I(Sa) current in neurons - channel properties are modulated by interactions with other alpha subunits & with regulatory subunits - phosphorylated on Ser & Thr - homotetramer or heterotetramer with KCND1 &/or KCND3 - interacts with DPP6, DLG4 & NCS1/FREQ (putative) - interacts with DLG1 - associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 & KCNIP4 - probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 & KCND2 - the KCND2-KCNIP2 channel complex contains 4 KCND2 & 4 KCNIP2 subunits - interacts with FLNA, FLNC & DPP10 Structure: - the segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position - belongs to the K⁺ channel family, D (Shal) (TC 1.A.1.2) subfamily, Kv4.2/KCND2 sub-subfamily Compartment: - cell membrane; multi-pass membrane protein - cell projection, dendrite - detected in dendrites in cultured hippocampal neurons - association with KCNIP2 probably enhances cell surface expression Expression: - highly expressed throughout the brain - expression is very low or absent in other tissues

General

glycoprotein K+ channel subfamily D phosphoprotein transmembrane 6 protein

Properties

SIZE: entity length = 630 aa MW = 71 kD COMPARTMENT: plasma membrane MOTIF: cytoplasmic domain {1-183} MOTIF: KCNIP2 interaction {2-20} KCNIP1 interaction {7-11} Thr phosphorylation site {T38} KCNIP1 interaction {71-90} Zn+2-binding site SITE: 105-105 Zn+2-binding site SITE: 132-132 Zn+2-binding site SITE: 133-133 transmembrane domain {184-204} exoplasmic loop {205-224} transmembrane domain {225-245} cytoplasmic loop {246-259} transmembrane domain {260-280} exoplasmic loop {281-289} transmembrane domain {290-310} cytoplasmic loop {311-323} transmembrane domain {324-344} exoplasmic loop {345-384} MOTIF: peptide motif {370-375} transmembrane domain {385-405} cytoplasmic domain {406-630} MOTIF: Ser phosphorylation site {S548} Ser phosphorylation site {S552} Thr phosphorylation site {T602} Thr phosphorylation site {T607} Ser phosphorylation site {S616} ION-PERMEABILITY: K+

Database Correlations

OMIM 605410 UniProt Q9NZV8 PFAM correlations Entrez Gene 3751 Kegg hsa:3751

References

UniProt :accession Q9NZV8