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K+ voltage-gated channel subfamily D member 1; voltage-gated K+ channel subunit Kv4.1 (KCND1)
Function:
- pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type K+ channels
- may contribute to I(To) current in heart & I(Sa) current in neurons
- channel properties are modulated by interactions with other alpha subunits & with regulatory subunits
- homotetramer or heterotetramer with KCND2 &/or KCND3
- associates with the regulatory subunits KCNIP1, KCNIP2, KCNIP3 & KCNIP4 (putative)
- interacts with DPP10 (probable)
Structure:
- the segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
- belongs to the K+ channel family, D (Shal) (TC 1.A.1.2) subfamily, Kv4.1/KCND1 sub-subfamily
Compartment: membrane
Expression:
- widely expressed
- highly expressed in brain, in particular in cerebellum & thalamus
- detected at lower levels in the other parts of the brain
General
glycoprotein
K+ channel subfamily D
transmembrane 6 protein
Properties
SIZE: entity length = 647 aa
MW = 71 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-184}
MOTIF: KCNIP2 interaction {2-20}
Zn+2-binding site
SITE: 104-104
Zn+2-binding site
SITE: 131-131
Zn+2-binding site
SITE: 132-132
transmembrane domain {185-205}
exoplasmic loop {206-226}
transmembrane domain {227-247}
cytoplasmic loop {248-261}
transmembrane domain {262-282}
exoplasmic loop {283-291}
transmembrane domain {292-312}
cytoplasmic loop {313-325}
transmembrane domain {326-346}
exoplasmic loop {347-386}
MOTIF: N-glycosylation site {N352}
N-glycosylation site {N355}
peptide motif {372-377}
transmembrane domain {387-407}
cytoplasmic domain {408-647}
ION-PERMEABILITY: K+
Database Correlations
OMIM 300281
UniProt Q9NSA2
PFAM correlations
Entrez Gene 3750
Kegg hsa:3750
References
UniProt :accession Q9NSA2