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K+ voltage-gated channel subfamily C member 4; KSHIIIC; voltage-gated K+ channel subunit Kv3.4 (KCNC4)
Function:
- mediates voltage-dependent K+ ion permeability of excitable membranes
- opens & closes in response to the voltage difference across the membrane
- forms a K+-selective channel through which K+ may pass in accordance with the electrochemical gradient
- phosphorylation of Ser in the inactivation gate inhibits rapid channel closure
- homotetramer (probable)
- heterotetramer of K+ channel proteins (putative)
Structure:
- the segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
- the tail may be important in modulation of channel activity &/or targeting of the channel to specific subcellular compartments
- belongs to the K+ channel family, C (Shaw) (TC 1.A.1.2) subfamily, Kv3.4/KCNC4 sub-subfamily
Compartment: membrane
Alternative splicing: named isoforms=2
General
glycoprotein
K+ channel subfamily C
phosphoprotein
transmembrane 6 protein
Properties
SIZE: entity length = 635 aa
MW = 70 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-226}
MOTIF: Inactivation gate {1-28}
Ser phosphorylation site {S8}
Ser phosphorylation site {S9}
Ser phosphorylation site {S15}
Ser phosphorylation site {S21}
transmembrane domain {227-247}
exoplasmic loop {248-277}
MOTIF: N-glycosylation site {N256}
N-glycosylation site {N265}
transmembrane domain {278-298}
cytoplasmic loop {299-312}
transmembrane domain {313-333}
exoplasmic loop {334-344}
transmembrane domain {345-364}
cytoplasmic loop {365-380}
transmembrane domain {381-401}
exoplasmic loop {402-451}
MOTIF: peptide motif {436-441}
transmembrane domain {452-472}
cytoplasmic domain {473-635}
ION-PERMEABILITY: K+
Database Correlations
OMIM 176265
UniProt Q03721
PFAM correlations
Entrez Gene 3749
Kegg hsa:3749
References
UniProt :accession Q03721