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K+ voltage-gated channel subfamily C member 1; NGK2; voltage-gated K+ channel subunit Kv3.1; voltage-gated K+ channel subunit Kv4 (KCNC1)
Function:
- mediates voltage-dependent K+ permeability of excitable membranes
- channels open or close in response to the voltage difference across the membrane
- the protein forms a K+-selective channel through which K+ may pass in accordance with the electrochemical gradient
- heteromultimer with KCNG3, KCNG4 & KCNV2
Structure:
- the segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
- the tail may be important in modulation of channel activity &/or targeting of the channel to specific subcellular compartments
- belongs to the K+ channel family, C (Shaw) (TC 1.A.1.2) subfamily, Kv3.1/KCNC1 sub-subfamily
Compartment: membrane
General
glycoprotein
K+ channel subfamily C
phosphoprotein
transmembrane 6 protein
Properties
SIZE: entity length = 511 aa
MW = 58 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-190}
MOTIF: Tyr phosphorylation site {Y188}
transmembrane domain {191-209}
exoplasmic loop {210-247}
MOTIF: N-glycosylation site {N220}
N-glycosylation site {N229}
transmembrane domain {248-267}
cytoplasmic loop {268-276}
transmembrane domain {277-295}
exoplasmic loop {296-308}
transmembrane domain {309-331}
cytoplasmic loop {332-344}
transmembrane domain {345-366}
exoplasmic loop {367-414}
MOTIF: peptide motif {400-405}
transmembrane domain {415-436}
cytoplasmic domain {437-511}
ION-PERMEABILITY: K+
Database Correlations
OMIM 176258
UniProt P48547
PFAM correlations
Entrez Gene 3746
References
UniProt :accession P48547