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K+ voltage-gated channel subfamily B member 2; voltage-gated K+ channel subunit Kv2.2 (KCNB2)
Function:
- mediates voltage-dependent K+ permeability of excitable membranes
- channels open or close in response to the voltage difference across the membrane, letting K+ pass in accordance with the electrochemical gradient
- phosphorylated (putative)
- heteromultimer with KCNS1, KCNS2 & KCNS3
Structure:
- the segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
- the tail may be important in modulation of channel activity &/or targeting of the channel to specific subcellular compartments
- belongs to the K+ channel family, B (Shab) (TC 1.A.1.2) subfamily, Kv2.2/KCNB2 sub-subfamily
Compartment: membrane
General
glycoprotein
K+ channel subfamily B
transmembrane 6 protein
Properties
SIZE: entity length = 911 aa
MW = 103 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-190}
transmembrane domain {191-212}
exoplasmic loop {213-232}
transmembrane domain {233-253}
cytoplasmic loop {254-263}
transmembrane domain {264-284}
exoplasmic loop {285-298}
MOTIF: N-glycosylation site {N287}
transmembrane domain {299-320}
cytoplasmic loop {321-334}
transmembrane domain {335-355}
exoplasmic loop {356-395}
MOTIF: peptide motif {381-386}
transmembrane domain {396-416}
cytoplasmic domain {417-911}
ION-PERMEABILITY: K+
Database Correlations
OMIM 607738
UniProt Q92953
PFAM correlations
Entrez Gene 9312
Kegg hsa:9312
References
UniProt :accession Q92953