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K+ voltage-gated channel subfamily A member 6; voltage-gated K+ channel subunit Kv1.6; HBK2 (KCNA6)
Function:
- mediates voltage-dependent K+ permeability of excitable membranes
- assumes opened or closed conformation in response to voltage difference across membrane
- forms a K+-selective channel through which K+ may pass in accordance with their electrochemical gradient
- heterotetramer of K+ channel proteins
Structure:
- the N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity &/or targeting of the channel to specific subcellular compartments
- the segment S4 is probably the voltage-sensor & is characterized by a series of positively charged amino acids at every third position
- belongs to the K+ channel family, A (Shaker) subfamily
Compartment: membrane
General
glycoprotein
phosphoprotein
voltage-gated K+ channel alpha subunit
Properties
SIZE: entity length = 529 aa
MW = 59 kD
COMPARTMENT: plasma membrane
MOTIF: Thr phosphorylation site {T8}
N-glycosylation site {N46}
transmembrane domain {175-193}
transmembrane domain {263-284}
cysteine residue {C285}
MODIFICATION: palmitate
COMPARTMENT: membrane
transmembrane domain {296-316}
transmembrane domain {340-360}
transmembrane domain {376-396}
peptide motif {422-427}
transmembrane domain {437-457}
Ser phosphorylation site {S511}
peptide motif {527-529}
ION-PERMEABILITY: K+
Database Correlations
OMIM 176257
UniProt P17658
PFAM correlations
Entrez Gene 3742
Kegg hsa:3742
References
UniProt :accession P17658