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K+ voltage-gated channel subfamily A member 5 (voltage-gated K+ channel subunit Kv1.5, HK2, HPCN1, KCNA5)
Function:
- mediates voltage-dependent K+ permeability of excitable membranes
- assumes opened or closed conformations in response to voltage difference across membrane
- K+-selective channel through which K+ may pass in accordance with the electrochemical gradient
- may play a role in regulating the secretion of insulin in normal pancreatic islets
- heterotetramer of K+ channel proteins
- interacts via its PDZ-binding motif with DLG1
- forms a ternary complex with DLG1 & CAV3 (putative)
Structure:
- amino terminus may be important in determining rate of inactivation of channe
- C-terminal PDZ-binding motif may play a role in modulation of channel activity &/or targeting of the channel to specific subcellular compartments
- segment S4 is probably the voltage-sensor; characterized by a series of positively charged amino acids at every third position
- belongs to the K+ channel family, A (Shaker) subfamily
Compartment: membrane
Expression: pancreatic islets & insulinoma
General
glycoprotein
phosphoprotein
voltage-gated K+ channel alpha subunit
Properties
SIZE: entity length = 613 aa
MW = 67 kD
COMPARTMENT: plasma membrane
MOTIF: 2 X 11 AA tandem repeat of D-[SP]-G-V-R- P-L-P-P-L-P {61-82}
MOTIF: 1 {61-71}
2 {72-82}
glutamate-rich region {94-99}
MOTIF: glutamate residue (SEVERAL)
N-glycosylation site {N125}
N-glycosylation site {N190}
transmembrane domain {251-269}
transmembrane domain {325-345}
cysteine residue {C346}
MODIFICATION: palmitate
COMPARTMENT: membrane
transmembrane domain {356-377}
glycine-rich region {382-387}
transmembrane domain {398-419}
transmembrane domain {434-455}
Selectivity filter {480-485}
transmembrane domain {495-516}
Ser phosphorylation site {S557}
PDZ recognition motif
NAME: PDZ recognition motif
SITE: 611-613
FOR-BINDING-VIA: PDZ domain
ION-PERMEABILITY: K+
Database Correlations
OMIM 176267
MORBIDMAP 176267
UniProt P22460
PFAM correlations
References
UniProt :accession P22460