Search
K+ voltage-gated channel subfamily A member 4 (voltage-gated K+ channel subunit Kv1.4, HK1, HPCN2, HBK4, HUKII, KCNA4, KCNA4L)
Function:
- mediates voltage-dependent K+ permeability of excitable membranes
- assumes opened or closed conformations in response to voltage difference across membrane
- forms a K+-selective channel through which K+ may pass in accordance with the electrochemical gradient
- heterotetramer of K+ channel proteins
- binds PDZ domains of DLG1, DLG2 & DLG4
- interacts with OPRS1
Structure:
- N-terminus may be important in determining the rate of inactivation of the channel
- tail may play a role in modulation of channel activity &/or targeting of the channel to specific subcellular compartments
- segment S4 is probably the voltage-sensor; characterized by a series of positively charged amino acids at every third position
- belongs to the K+ channel family, a (Shaker) subfamily
Compartment: membrane
General
glycoprotein
phosphoprotein
voltage-gated K+ channel alpha subunit
Properties
SIZE: entity length = 653 aa
MW = 73 kD
COMPARTMENT: plasma membrane
MOTIF: histidine-rich region {62-65}
MOTIF: histidine residue (SEVERAL)
Ser phosphorylation site {S90}
Ser phosphorylation site {S122}
glutamate-rich region {123-137}
MOTIF: glutamate residue (SEVERAL)
glycine-rich region {162-165}
N-glycosylation site {N181}
transmembrane domain {308-326}
N-glycosylation site {N352}
transmembrane domain {371-392}
transmembrane domain {404-424}
glutamine-rich region {433-436}
MOTIF: glutamine residue (SEVERAL)
transmembrane domain {443-461}
transmembrane domain {478-497}
Selectivity filter {524-529}
transmembrane domain {539-561}
Ser phosphorylation site {S599}
PDZ recognition motif
NAME: PDZ recognition motif
SITE: 651-653
FOR-BINDING-VIA: PDZ domain
ION-PERMEABILITY: K+
Database Correlations
OMIM 176266
UniProt P22459
PFAM correlations
References
UniProt :accession P22459