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K+ voltage-gated channel subfamily A member 2; voltage-gated K+ channel subunit Kv1.2; HBK5; NGK1; HUKIV (KCNA2, RBK2, RCK5, MK2)
Function:
- mediates the voltage-dependent K+ permeability of excitable membranes
- assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a K+-selective channel through which K+ may pass in accordance with the electrochemical gradient
- heterotetramer of K+ channel proteins
- binds PDZ domains of DLG1, DLG2 & DLG4 (putative)
Structure:
- N-terminus may be important in determining the rate of inactivation of the channel
- the tail may play a role in modulation of channel activity &/or targeting of the channel to specific subcellular compartments
- segment S4 is probably the voltage-sensor; it is characterized by a series of positively charged amino acids at every third position
- belongs to the K+ channel family, A (Shaker) subfamily
Compartment: membrane
General
glycoprotein
voltage-gated K+ channel alpha subunit
Properties
SIZE: entity length = 499 aa
MW = 57 kD
COMPARTMENT: plasma membrane
MOTIF: N-glycosylation site {N38}
transmembrane domain {164-182}
N-glycosylation site {N207}
transmembrane domain {222-243}
cysteine residue {C244}
MODIFICATION: palmitate
COMPARTMENT: membrane
transmembrane domain {255-275}
transmembrane domain {293-311}
transmembrane domain {328-347}
Selectivity filter {374-379}
transmembrane domain {389-411}
Thr phosphorylation site {T421}
Tyr phosphorylation site {Y429}
Thr phosphorylation site {T433}
Ser phosphorylation site {S449}
PDZ recognition motif
NAME: PDZ recognition motif
SITE: 497-499
FOR-BINDING-VIA: PDZ domain
ION-PERMEABILITY: K+
Database Correlations
OMIM 176262
UniProt P16389
PFAM correlations
Entrez Gene 3737
Kegg hsa:3737
References
UniProt :accession P16389