recombining binding protein suppressor of hairless; J kappa-recombination signal-binding protein; RBP-J kappa; RBP-J; RBP-JK; CBF-1; renal carcinoma antigen NY-REN-30 (RBPJ, IGKJRB, IGKJRB1, RBPJK, RBPSUH)

Function: - transcriptional regulator - role in notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations - acts as a transcriptional repressor when it is not associated with notch proteins - when associated with some notch protein, it acts as a transcriptional activator that activates transcription of notch target genes - probably represses or activates transcription via recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively - specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence - interacts with activated NOTCH1, NOTCH2 or NOTCH₃ - interacts with MINT/SHARP; this interaction may mediate recruitment of large corepressor complexes containing proteins such as HDAC1, HDAC2, NCOR2, SAP30, FHL1/KYOT2 & CIR1 - interacts with EP300, MAML1 & PTF1A - interacts with Epstein-Barr virus EBNA2, EBNA3, EBNA4 & EBNA6 Structure: - belongs to the Su(H) family - contains 1 IPT/TIG domain Compartment: nucleus Alternative splicing: named isoforms=6; APCR-1, APCR-2, APCR-3 Note: - despite some similarity with the phage integrase family, it has no recombinase activity

Properties

SIZE: entity length = 500 aa MW = 56 kD COMPARTMENT: cell nucleus MOTIF: DNA-binding motif SITE: 58-65 DNA-binding motif SITE: 192-201 DNA-binding motif SITE: 265-297 IPT/TIG {355-445}

Database Correlations

OMIM 147183 UniProt Q06330 PFAM correlations Entrez Gene 3516 Kegg hsa:3516

References

UniProt :accession Q06330