Jun dimerization protein 2 (JDP2)

Function: - component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins - involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis & antitumogeneris - can also function as a repressor by recruiting histone deacetylase 3 (HDAC3) to the promoter region of JUN - may control transcription via direct regulation of the modification of histones & the assembly of chromatin - forms homodimer or heterodimer with JUN, JUNB, JUND, CEBPG & ATF2 thereby inhibiting transactivation by JUN, ATF2 & CEBPG (putative) - binds multiple DNA elements such as cAMP-response element (CRE) & TPA response element (TRE) either as homodimer or heterodimer (putative) - phosphorylation of Thr-148 by MAPK8 in response to different stress conditions such as, UV irradiation, oxidatives stress & anisomycin treatments Structure: - belongs to the bZIP family, ATF subfamily - contains 1 bZIP domain Compartment: nucleus (probable)

General

DNA-binding protein phosphoprotein transcription factor (TF)

Properties

SIZE: entity length = 163 aa MW = 19 kD COMPARTMENT: cell nucleus MOTIF: DNA-binding motif SITE: 77-92 leucine zipper SITE: 100-135 FOR-BINDING-VIA: leucine zipper Thr phosphorylation site {T148}

Database Correlations

OMIM 608657 UniProt Q8WYK2 Pfam PF07716 Kegg hsa:1229

References

UniProt :accession Q8WYK2