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Junction-mediating & -regulatory protein (JMY)
Function:
- cofactor that increases p53/TP53 response via its interaction with p300/EP300
- increases p53/TP53-dependent transcription & apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage (putative)
- interacts with p300/EP300, the complex being recruited to activated p53/TP53
- interacts with TTC5 (putative)
- ubiquitinated by MDM2, leading to its subsequent degradation by the proteasome
- in case of DNA damage, interaction with MDM2 is altered, preventing degradation & allowing interaction with p300/EP300 & its function in p53/TP53 stress response
Structure: contains 1 WH2 domain
Compartment: nucleus (putative)
Alternative splicing: named isoforms=2
Expression: induced by E2F
General
nuclear protein
Properties
SIZE: entity length = 988 aa
MW = 111 kD
COMPARTMENT: cell nucleus
MOTIF: p300/EP300 interaction {1-126}
coiled coil {324-360}
p300/EP300 interaction {478-567}
MOTIF: coiled coil {489-541}
coiled coil {590-621}
proline-rich region
SITE: 781-827
MOTIF: proline residue (SEVERAL)
WH2 {921-938}
Database Correlations
OMIM 604279
UniProt Q8N9B5
Pfam PF02205
Kegg hsa:1337
References
UniProt :accession Q8N9B5