Junctional adhesion molecule-like (Dendritic cell-specific protein CREA7-1, Adhesion molecule interacting with CXADR antigen 1) (AMICA1 JAML UNQ722/PRO1387)

Function: - may function in transmigration of leukocytes through epithelial & endothelial tissues - at plasma membrane of polymorphonuclear leukocytes, mediates adhesive interactions with CXADR, a protein of the junctional complex of epithelial cells - enhances myeloid leukemia cell adhesion to endothelial cells - interacts with CXADR Structure: - belongs to the immunoglobulin superfamily - contains 2 Ig-like V-type domains (immunoglobulin-like) Ig-like V-type domain 2 mediates interaction with CXADR Compartment: - cell junction - localized at the plasma membrane in areas of cell-cell contacts & at the cell surface of PMN Alternative splicing: named isoforms=3 Expression: - expression is restricted to the hematopoietic tissues & liver - expressed in fetal liver, spleen & thymus - up-regulated upon retinoic acid, Me2SO & PMA treatment in differentiating myeloid leukemia cells

General

glycoprotein membrane protein

Properties

SIZE: MW = 44 kD entity length = 394 aa COMPARTMENT: cellular membrane MOTIF: signal sequence {1-19} immunoglobulin superfamily domain {20-132} MOTIF: cysteine residue {C42} MODIFICATION: cysteine residue {C116} N-glycosylation site {N76} cysteine residue {C116} MODIFICATION: cysteine residue {C42} immunoglobulin superfamily domain {137-250} MOTIF: cysteine residue {C155} MODIFICATION: cysteine residue {C234} N-glycosylation site {N231} cysteine residue {C234} MODIFICATION: cysteine residue {C155} transmembrane domain {276-296}

Database Correlations

UniProt Q86YT9 Pfam PF07686

References

UniProt :accession Q86YT9