jun/CREB complex

Binds to CRE sites.

General

DNA-binding protein transcription factor complex

Properties

COMPARTMENT: cell nucleus MOTIF: DNA-binding motif SUBUNITS: CRE-BP1 :MOTIF basic helix-loop-helix :MOTIF basic DNA-binding motif helix-loop-helix :QUALITIES intermolecular bond :EFFECTOR_BOUND C_JUN_PROTEIN :BOUND_VIA HELIX_LOOP_HELIX :SITE CBHLH leucine zipper :LEUCINES 4 :QUALITIES INTERMOLECULAR_BOND :EFFECTOR_BOUND C_JUN_PROTEIN :BOUND_VIA leucine zipper :SITE C-TERMINAL c-jun proto-oncogene protein MOTIF: Thr phosphorylation site {T2} Thr phosphorylation site {T8} Ser phosphorylation site {S58} Thr phosphorylation site {T62} Ser phosphorylation site {S63} Ser phosphorylation site {S73} Thr phosphorylation site {T89} Thr phosphorylation site {T93} Thr phosphorylation site {T239} Ser phosphorylation site {S243} hinge region basic helix-loop-helix {C-TERMINAL} MOTIF: basic DNA-binding motif MOTIF: cysteine residue {X+1} helix-loop-helix NAME: helix-loop-helix EFFECTOR-BOUND: CRE-BP1 BOUND-VIA: helix-loop-helix FOR-BINDING-VIA: helix-loop-helix FOR-BINDING-OF: DNA motif FOR-BINDING-VIA: helix-loop-helix leucine zipper SITE: C-TERMINAL EFFECTOR-BOUND: CRE-BP1 BOUND-VIA: leucine zipper FOR-BINDING-VIA: leucine zipper LEUCINES: 5 Ser phosphorylation site {S249} DNA-binding motif SITE: 257-276 MOTIF: cysteine residue {269} arginine residue {272} helix-loop-helix NAME: helix-loop-helix FOR-BINDING-VIA: helix-loop-helix leucine zipper SITE: 280-308 FOR-BINDING-VIA: leucine zipper MOTIF: Thr phosphorylation site {T286}

References

Morgan & Curran The Neuroscientist 1:68 1995