protein Jumonji; Jumonji/ARID domain-containing protein 2 (JARID2, JMJ)

Function: - regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart & liver development, neural tube fusion process & hematopoiesis - acts by modulating histone methyltransferase activity & promoting recruitment of histone methyltransferase complexes to their target genes - binds DNA & mediates recruitment of the PRC2 complex to target genes in embryonic stem cells - does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes - in embryonic stem cells, associates with the PRC2 complex & inhibits trimethylation of Lys-27 of histone H3 (H3K27me3) by the PRC2 complex, thus playing a key role in differentiation of embryonic stem cells & normal development - in cardiac cells, required to repress expression of cyclin-D1 CCND1) by activating methylation of Lys-9 of histone H3 (H3K9me) by the GLP1/EHMT1 & G9a/EHMT2 histone methyltransferases - also acts as a transcriptional repressor of ANF via its interaction with GATA4 & NKX2-5 - participates in negative regulation of cell proliferation signaling - associates with a histone methyltransferase complex containing GLP1/EHMT1 & G9a/EHMT2 - interacts with SUZ12; the interaction is direct - interacts with GATA4 (via the N-terminal region) - interacts with NKX2-5 (via the C-terminal region) - interacts with RB1 - interacts with ZNF496 (putative) - associates with the PRC2 complex, which includes EED, EZH1, EZH2, SUZ12, RBBP4 & AEBP2; JARID2 is probably not a core component of the PRC2 complex & associates to PRC2 via its interaction with SUZ12 Structure: - the ARID domain is required to target the PRC2 complex to its target genes (putative) - the GSGFP motif is required for the interaction with SUZ12 - contains 1 ARID domain - contains 1 JmjC domain - contains 1 JmjN domain Compartment: - nucleus - colocalizes with the PRC2 complex on chromatin Alternative splicing: named isoforms=2 Expression: - during embryogenesis, predominantly expressed in neurons & particularly in dorsal root ganglion cells

Properties

SIZE: entity length = 1246 aa MW = 139 kD COMPARTMENT: cell nucleus MOTIF: nuclear translocation signal {104-110} JmjN {557-598} ARID {621-713} GSGFP {874-878} JmjC {884-1048} serine-rich region {1234-1246} MOTIF: serine residue (SEVERAL)

Database Correlations

OMIM 601594 UniProt Q92833 PFAM correlations Entrez Gene 3720 Kegg hsa:3720

References

UniProt :accession Q92833