Search
lysine-specific demethylase 4C; gene amplified in squamous cell carcinoma 1 protein; GASC-1 protein; JmjC domain-containing histone demethylation protein 3C; Jumonji domain-containing protein 2C (KDM4C, GASC1, JHDM3C, JMJD2C, KIAA0780)
Function:
- histone demethylase
- specifically demethylates Lys-9 & Lys-36 residues of histone H3, thua playing a role in histone code
- does not demethylate histone H3 Lys-4, H3 Lys-27 nor H4 Lys-20
- demethylates trimethylated H3 Lys-9 & H3 Lys-36
- no activity on mono- & dimethylated Lys
- demethylation of Lys generates formaldehyde & succinate
Cofactor:
- binds 1 Fe+2 ion per subunit (putative)
Structure:
- the 2 Tudor domains recognize & bind methylated histones
- double Tudor domain has an interdigitated structure & the unusual fold is required for its ability to bind methylated histone tails (putative)
- belongs to the JHDM3 histone demethylase family
- contains 1 JmjC domain
- contains 1 JmjN domain
- contains 2 PHD-type Zn+2 fingers
- contains 2 Tudor domains
Compartment: nucleus (putative)
Alternative splicing: named isoforms=2
Expression:
- overexpressed in several esophageal squamous cell carcinomas
Related
esophageal cancer
squamous cell carcinoma (SCC)
General
histone demethylase
phosphoprotein
zinc finger protein
Properties
SIZE: entity length = 1056 aa
MW = 120 kD
COMPARTMENT: cell nucleus
MOTIF: JmjN {16-58}
binding site
SITE: 134-134
FOR-BINDING-OF: Alpha-ketoglutarate
JmjC {144-310}
MOTIF: Iron [Fe]-binding site
SITE: 190-190
Iron [Fe]-binding site
SITE: 192-192
binding site
SITE: 200-200
FOR-BINDING-OF: Alpha-ketoglutarate
binding site
SITE: 208-208
FOR-BINDING-OF: Alpha-ketoglutarate
Zn+2-binding site
SITE: 236-236
Zn+2-binding site
SITE: 242-242
Iron [Fe]-binding site
SITE: 278-278
Zn+2-binding site
SITE: 308-308
Zn+2-binding site
SITE: 310-310
Ser phosphorylation site {S392}
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 689-747
EFFECTOR-BOUND: Zn+2
Zn finger PHD-type
NAME: Zn finger PHD-type
SITE: 809-865
EFFECTOR-BOUND: Zn+2
Tudor domain
SITE: 877-934
Tudor domain
SITE: 935-991
Database Correlations
OMIM 605469
UniProt Q9H3R0
PFAM correlations
Entrez Gene 23081
Kegg hsa:23081
ENZYME 1.14.11._
References
- UniProt :accession Q9H3R0
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/GASC1ID432.html