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JmjC domain-containing protein 2D; JmjC domain-containing histone demethylation protein 3D; Jumonji domain-containing protein 2D (JMJD2D, JHDM3D, KDM4D)
Function:
- histone demethylase
- specifically demethylates Lys-9 of histone H3, thus plays a role in histone code
- does not demethylate histone H3 Lys-4, H3 Lys-27, H3 Lys-36 nor histone H4 Lys-20
- demethylates both di- & trimethylated H3 Lys-9 residue, no activity on monomethylated residues
- demethylation of Lys generates formaldehyde & succinate
Cofactor: binds 1 Fe+2 ion per subunit
Structure:
- belongs to the JHDM3 histone demethylase family
- contains 1 JmjC domain
- contains 1 JmjN domain
Compartment: nucleus
General
dioxygenase
histone demethylase
JmjC domain-containing protein (JMJD)
Properties
SIZE: MW = 58 kD
entity length = 520 aa
COMPARTMENT: cell nucleus
MOTIF: JmjN {15-57}
binding site
SITE: 133-133
FOR-BINDING-OF: alpha-ketoglutarate
JmjC {143-309}
MOTIF: Iron [Fe]-binding site
SITE: 189-189
Iron [Fe]-binding site
SITE: 191-191
binding site
SITE: 199-199
FOR-BINDING-OF: alpha-ketoglutarate
binding site
SITE: 207-207
FOR-BINDING-OF: alpha-ketoglutarate
Zn+2-binding site
SITE: 235-235
Zn+2-binding site
SITE: 241-241
Iron [Fe]-binding site
SITE: 277-277
Zn+2-binding site
SITE: 307-307
Zn+2-binding site
SITE: 309-309
Database Correlations
UniProt Q6B0I6
PFAM correlations
References
UniProt :accession Q6B0I6