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JmjC domain-containing protein-1B; Jumonji domain-containing protein 1B; nuclear protein 5qNCA (KDM3B, JMJD1B, JHDM2B, KIAA1082, C5orf7)
Function:
- histone demethylase
- specifically demethylates Lys-9 of histone H3, thus plays a role in histone code
- demethylation of Lys generates formaldehyde & succinate
Cofactor: binds 1 Fe+2 ion per subunit
Structure:
- belongs to the JHDM2 histone demethylase family
- contains 1 JmjC domain
- Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate association with nuclear receptors
Compartment: nucleus
Alternative splicing: named isoforms=3
Expression:
- highly expressed in placenta, skeletal muscle, kidney, heart & liver
Genetics:
- gene located in 5q region of the genome which is deleted in del(5q) interstitial deletion, a frequent deletion found in myeloid leukemias & myelodysplasias
General
dioxygenase
histone demethylase
JmjC domain-containing protein (JMJD)
metalloprotein
phosphoprotein
Properties
SIZE: MW = 192 kD
entity length = 1761 aa
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S291}
serine-rich region {647-744}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S798}
Zinc finger
NAME: Zinc finger
SITE: 1031-1056
EFFECTOR-BOUND: Zn+2
LXXLL {1293-1297}
JmjC {1498-1721}
MOTIF: Iron [Fe]-binding site
SITE: 1560-1560
Iron [Fe]-binding site
SITE: 1562-1562
Iron [Fe]-binding site
SITE: 1689-1689
Database Correlations
UniProt Q7LBC6
Pfam PF02373
References
UniProt :accession Q7LBC6